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, 21 (37), 10669-74

Five-year Sequential Changes in Secondary Antibiotic Resistance of Helicobacter Pylori in Taiwan


Five-year Sequential Changes in Secondary Antibiotic Resistance of Helicobacter Pylori in Taiwan

I-Ting Wu et al. World J Gastroenterol.


Aim: To determine changes in the antibiotic resistance of Helicobacter pylori (H. pylori) in southern Taiwan after failure of first-line standard triple therapy.

Methods: We analyzed 137 H. pylori-infected isolates from patients who experienced eradication failure after standard first-line triple therapy from January 2010 to December 2014. The H. pylori strains were tested for susceptibility to amoxicillin, clarithromycin, levofloxacin, metronidazole and tetracycline using the E-test method. The minimal inhibitory concentration (MIC) was determined by the agar dilution test. MIC values of ≥ 0.5, ≥ 1, ≥ 1, ≥ 4 and ≥ 8 mg/L were considered to be the resistance breakpoints for amoxicillin, clarithromycin, levofloxacin, tetracycline and metronidazole, respectively.

Results: A high resistance rate was found for clarithromycin (65%-75%) and metronidazole (30%-40%) among patients who failed first-line standard therapy. The resistance levels to amoxicillin and tetracycline remained very low; however, levofloxacin resistance was as high as 37.5% in 2010 but did not increase any further during the past 5 years. The rates of resistance to these antibiotics did not show a statistically significant upward or downward trend.

Conclusion: Antibiotic resistance of H. pylori remains a problem for the effective eradication of this pathogen and its associated diseases in Taiwan. High clarithromycin resistance indicated that this antibiotic should not be prescribed as a second-line H. pylori eradication therapy. Moreover, levofloxacin-based second-line therapy should be used cautiously, and the local resistance rates should be carefully monitored.

Keywords: Antibiotic resistance; Failed first-line therapy; Five-year sequential changes; Helicobacter pylori; Southern Taiwan.


Figure 1
Figure 1
The trend of annual antibiotic resistance rates in the treatment of Helicobacter pylori. Values located above 15% (horizontal line) indicated the intention-to-treat cure rate categories below C (fair, 85%-89%)[39].

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