NSAIDs and Cardiovascular Diseases: Role of Reactive Oxygen Species

Oxid Med Cell Longev. 2015;2015:536962. doi: 10.1155/2015/536962. Epub 2015 Sep 20.

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most commonly used drugs worldwide. NSAIDs are used for a variety of conditions including pain, rheumatoid arthritis, and musculoskeletal disorders. The beneficial effects of NSAIDs in reducing or relieving pain are well established, and other benefits such as reducing inflammation and anticancer effects are also documented. The undesirable side effects of NSAIDs include ulcers, internal bleeding, kidney failure, and increased risk of heart attack and stroke. Some of these side effects may be due to the oxidative stress induced by NSAIDs in different tissues. NSAIDs have been shown to induce reactive oxygen species (ROS) in different cell types including cardiac and cardiovascular related cells. Increases in ROS result in increased levels of oxidized proteins which alters key intracellular signaling pathways. One of these key pathways is apoptosis which causes cell death when significantly activated. This review discusses the relationship between NSAIDs and cardiovascular diseases (CVD) and the role of NSAID-induced ROS in CVD.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Arthritis / drug therapy
  • Cardiovascular Diseases / epidemiology
  • Cardiovascular Diseases / etiology*
  • Cytochrome P-450 Enzyme System / metabolism
  • Humans
  • Incidence
  • Lipoxygenase / metabolism
  • Mitochondria / drug effects
  • Mitochondria / metabolism
  • NADPH Oxidases / metabolism
  • Nitric Oxide Synthase / metabolism
  • Reactive Oxygen Species / metabolism*
  • Xanthine Oxidase / metabolism

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Reactive Oxygen Species
  • Cytochrome P-450 Enzyme System
  • Lipoxygenase
  • Nitric Oxide Synthase
  • Xanthine Oxidase
  • NADPH Oxidases