Reliability of malondialdehyde as a biomarker of oxidative stress in psychological disorders

Bioimpacts. 2015;5(3):123-7. doi: 10.15171/bi.2015.20. Epub 2015 Jul 26.

Abstract

Despite very wide variations of malondialdehyde (MDA) concentrations in biological samples, it is still used as a biomarker of oxidative stress in clinical investigations. In the current perspective study, we aimed to summarize a number of critical analytical points for determination of MDA. Technical problems and controversial findings in healthy people and some psychiatric disorders reveal that the reliability of MDA as a biomarker of oxidative stress n eeds to be re-evaluated by experts.

Keywords: Biomarker; Oxidative stress; Thiobarbitoric acid reactive substances.