A mammalian pexophagy target

Nat Cell Biol. 2015 Nov;17(11):1371-3. doi: 10.1038/ncb3253. Epub 2015 Oct 12.


Protein ubiquitylation in mammals is known to trigger selective autophagy of peroxisomes through a process termed pexophagy. The physiological peroxisomal target for pexophagy-related ubiquitylation has been controversial, but two studies have now identified the protein PEX5 as the real candidate.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Animals
  • Ataxia Telangiectasia Mutated Proteins / metabolism*
  • Autophagy*
  • Humans
  • Peroxisomes / metabolism*
  • Reactive Oxygen Species / metabolism*
  • Receptors, Cytoplasmic and Nuclear / metabolism*


  • Reactive Oxygen Species
  • Receptors, Cytoplasmic and Nuclear
  • Ataxia Telangiectasia Mutated Proteins