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Observational Study
, 139 (Pt A), 7-14

Nicotine and Carbon Monoxide Exposure From Inhalation of Cigarillo Smoke

Observational Study

Nicotine and Carbon Monoxide Exposure From Inhalation of Cigarillo Smoke

Bartosz Koszowski et al. Pharmacol Biochem Behav.


Background: There has been an increase in the use of cigarillos in the US. People who smoke cigarillos typically also regularly smoke cigarettes (dual users).

Methods: We compared puffing topography, biomarkers of acute exposure [exhaled carbon monoxide (COex) and plasma nicotine] and physiologic effects from usual brand cigarette and Black & Mild cigarillo smoking in dual users (N=23) in two laboratory sessions.

Results: Participants (21 men) smoked an average of 17.5cigarettes/day. Cigarillo consumption varied widely from as few as 1/week to daily. Participants were highly nicotine dependent (average FTND score: 6.3). There were statistically significant differences in smoking behavior between cigarette and cigarillo smoking in time to smoke, number of puffs, and total puff volume (all P<0.001). Average puff duration, interpuff interval average puff volume, and puff velocity did not differ between cigarettes and cigarillos. Nicotine boost was similar after both cigarettes and cigarillos. COex boost was significantly greater after cigarillo smoking compared to cigarette smoking (P<0.001).

Conclusions: The smoking pattern and exposure profile indicate that dual users inhale cigarillo smoke just as they inhale cigarette smoke thereby exposing themselves to considerable amounts of nicotine and other components of tobacco smoke. COex exposure results imply that cigarillo smoking may be associated with higher exposure to smoke-delivered volatile components of mainstream cigarillo smoke including carcinogens when compared to cigarettes.

Impact: The findings that cigarillos and cigarettes are smoked similarly in dual users are relevant to health and regulatory considerations on cigar products.

Keywords: Biomarkers; Cigarillos; Cigars; Exposure; Topography.

Conflict of interest statement

Competing interest statement:

The authors report no competing interests:


Figure 1
Figure 1. Puff by puff analysis
Puff parameters for cigarettes and cigarillos showing the first 3 puffs (1,2,3) and the last 3 puffs (X,Y,Z) from participants (N=23) smoking. Comparisons of the first 3 and last 3 puffs indicated significant (p<0.01) decreases in puff volume, puff duration and an increase in inter puff interval from cigarette and cigarillo smoking; puff velocity did not significantly change after either cigarettes or cigarillos.

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