Facile synthesis of glucose-sensitive chitosan-poly(vinyl alcohol) hydrogel: Drug release optimization and swelling properties

Int J Biol Macromol. 2016 Sep;90:75-80. doi: 10.1016/j.ijbiomac.2015.10.001. Epub 2015 Oct 14.


The study describes the development of glucose-sensitive hydrogel and optimization of bovine serum albumin release profile from the hydrogel. To enhance the glucose sensitivity and improve the swelling behaviors of the hydrogel system, boric acid crosslinking, and freeze-thawing cycle techniques were used to prepare chitosan-poly(vinyl alcohol) hydrogel. The structure of the resultant hydrogel was confirmed by scanning electron microscopy and Fourier transform infrared spectroscopy. The experimental results revealed that the swelling of the hydrogel was influenced by the pH of the medium, and the hydrogel displayed explicit glucose-sensitivity under physiological conditions. The values of the diffusion exponent range between 0.34 and 0.44 and the diffusion of water into the gel system are assumed to be pseudo-Fickian in nature. Under optimized conditions, the cumulative Bovine serum albumin (BSA) drug releases ranged between 69.33±1.95% and 86.45±1.16% at 37°C in the presence of glucose and pH 7.4, respectively.

Keywords: Chitosan; Drug release; Glucose response hydrogels; Optimization; PVA.

MeSH terms

  • Analysis of Variance
  • Animals
  • Cattle
  • Chitosan / chemistry*
  • Drug Liberation*
  • Glucose / chemistry*
  • Hydrogel, Polyethylene Glycol Dimethacrylate / chemical synthesis
  • Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry*
  • Hydrogen-Ion Concentration
  • Polyvinyl Alcohol / chemistry*
  • Serum Albumin, Bovine / metabolism
  • Spectroscopy, Fourier Transform Infrared


  • Hydrogel, Polyethylene Glycol Dimethacrylate
  • Serum Albumin, Bovine
  • Polyvinyl Alcohol
  • Chitosan
  • Glucose