Dark Blood Magnetic Resonance Lymphangiography Using Dual-Agent Relaxivity Contrast (DARC-MRL): A Novel Method Combining Gadolinium and Iron Contrast Agents

Jeffrey H Maki; Peter C Neligan; Noah Briller; Lee M Mitsumori; Gregory J Wilson

doi:10.1067/j.cpradiol.2015.08.003

Dark Blood Magnetic Resonance Lymphangiography Using Dual-Agent Relaxivity Contrast (DARC-MRL): A Novel Method Combining Gadolinium and Iron Contrast Agents

Curr Probl Diagn Radiol. 2016 May-Jun;45(3):174-9. doi: 10.1067/j.cpradiol.2015.08.003. Epub 2015 Aug 11.

Authors

Jeffrey H Maki¹, Peter C Neligan², Noah Briller³, Lee M Mitsumori⁴, Gregory J Wilson³

Affiliations

¹ Department of Radiology, University of Washington, Seattle, WA. Electronic address: jmaki@uw.edu.
² Department of Plastic Surgery, University of Washington, Seattle, WA.
³ Department of Radiology, University of Washington, Seattle, WA.
⁴ Department of Radiology, Straub Clinic and Hospital, Honolulu, HI.

PMID: 26460054
DOI: 10.1067/j.cpradiol.2015.08.003

Abstract

The objective of this study was to develop and demonstrate a technique to eliminate venous enhancement in contrast-enhanced magnetic resonance lymphangiography through shortening T2(⁎) in the blood pool, thus allowing for a lymphatic-only map. Administration of the blood-pool iron agent ferumoxtyol in addition to intracutaneous gadolinium during contrast-enhanced magnetic resonance lymphangiography allows for suppression of vascular structures to achieve venous-free lymphatic mapping.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Blood / diagnostic imaging
Contrast Media*
Ferrosoferric Oxide*
Gadolinium DTPA*
Humans
Image Enhancement / methods*
Lymphedema / diagnostic imaging*
Lymphography / methods
Magnetic Resonance Imaging / methods*
Phantoms, Imaging

Substances

Contrast Media
Gadolinium DTPA
Ferrosoferric Oxide