The Life Cycle of the Nephron Progenitor

Dev Cell. 2015 Oct 12;35(1):5-6. doi: 10.1016/j.devcel.2015.09.023.


Although we know that mesenchymal progenitors give rise to nephrons in the kidney, how they balance self-renewal versus differentiation is still unclear. In this issue of Developmental Cell, Chen et al. (2015) show that nephron progenitors age, but not necessarily irreversibly: old progenitors can be "rejuvenated" by a young crowd.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Communication*
  • Cell Differentiation*
  • Cellular Senescence*
  • Kidney / cytology*
  • Nephrons / cytology*
  • Organogenesis / physiology*
  • Stem Cells / cytology*