Vitamin B₁₂ deficiency-induced increase of osteoclastic bone resorption caused by abnormal renal resorption of inorganic phosphorus via Napi2a

Biosci Biotechnol Biochem. 2016;80(3):510-3. doi: 10.1080/09168451.2015.1095071. Epub 2015 Oct 13.


Vitamin B12 deficiency is a risk factor for bone disorders via mechanisms not fully understood. In this study, an increase in serum inorganic phosphorus (Pi) concentrations was associated with a vitamin B12 deficiency. Napi2a, a renal cotransporter for Pi reabsorption, accumulated on plasma membranes in a vitamin B12 deficiency suggests that vitamin B12 plays an important role in Pi homeostasis.

Keywords: Napi2a; bone disorder; inorganic phosphorus.

MeSH terms

  • Animals
  • Bone Resorption*
  • Homeostasis
  • Kidney / metabolism*
  • Osteoclasts / pathology*
  • Phosphates / metabolism*
  • Rats
  • Sodium-Phosphate Cotransporter Proteins, Type IIa / physiology*
  • Vitamin B 12 Deficiency / physiopathology*


  • Phosphates
  • Sodium-Phosphate Cotransporter Proteins, Type IIa