6-Mercaptopurine and other immunosuppressive agents in the treatment of Crohn's disease and ulcerative colitis

Gastroenterol Clin North Am. 1989 Mar;18(1):57-71.

Abstract

The role of immunosuppressives in the treatment of Crohn's disease and ulcerative colitis will be reviewed. This will include a comprehensive presentation of the uncontrolled and controlled studies in both diseases. The author's personal experiences with more than 400 patients will be summarized, including efficacy and short- and long-term toxicity. A review of the literature regarding the risk of superinfections and neoplasia will be presented. Finally, specific indications for the use of 6-MP/azathioprine will be listed.

Publication types

  • Review

MeSH terms

  • Azathioprine / therapeutic use
  • Colitis, Ulcerative / drug therapy*
  • Crohn Disease / drug therapy*
  • Humans
  • Immunosuppressive Agents / therapeutic use*
  • Mercaptopurine / therapeutic use*

Substances

  • Immunosuppressive Agents
  • Mercaptopurine
  • Azathioprine