Placebo-controlled trial of terlipressin (glypressin) in the management of acute variceal bleeding

J Clin Gastroenterol. 1989 Feb;11(1):58-60. doi: 10.1097/00004836-198902000-00014.

Abstract

In a double-blind trial 60% of acute variceal bleeding episodes were controlled with terlipressin (glypressin) compared with 37% in patients given placebo (NS). Rebleeding was more common in the placebo group so that at 5 days bleeding remained under control in 54% of patients treated with terlipressin compared with only 19% after placebo therapy (p less than 0.025). Blood transfusion requirements were similar in the two groups. Terlipressin appeared to be the most effective in those patients with severe hepatic dysfunction.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Acute Disease
  • Clinical Trials as Topic
  • Double-Blind Method
  • Esophageal and Gastric Varices / etiology
  • Esophageal and Gastric Varices / therapy*
  • Gastrointestinal Hemorrhage / etiology
  • Gastrointestinal Hemorrhage / therapy*
  • Humans
  • Liver Diseases, Alcoholic / complications
  • Lypressin / analogs & derivatives*
  • Lypressin / therapeutic use
  • Middle Aged
  • Random Allocation
  • Recurrence
  • Terlipressin

Substances

  • Lypressin
  • Terlipressin