Drug target identification through systems biology

Drug Discov Today Technol. 2015 Aug;15:17-22. doi: 10.1016/j.ddtec.2015.06.002. Epub 2015 Jul 17.

Abstract

To rationalise drug target selection, we should understand the role of putative targets in biological pathways quantitatively. We review here how experimental and computational network-based approaches can aid more rational drug target selection and illustrate this with results obtained for microbes and for cancer. Comparison of the drug response of biochemical networks in target cells and (healthy) host cells can reveal network-selective targets.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anti-Infective Agents / pharmacology
  • Antineoplastic Agents / pharmacology
  • Computational Biology*
  • Humans
  • Molecular Targeted Therapy*
  • Neoplasms / drug therapy
  • Neoplasms / pathology
  • Systems Biology / methods*

Substances

  • Anti-Infective Agents
  • Antineoplastic Agents