doi: 10.1126/science.2646710.
A Salmonella locus that controls resistance to microbicidal proteins from phagocytic cells
Affiliations
- PMID: 2646710
- DOI: 10.1126/science.2646710
Item in Clipboard
A Salmonella locus that controls resistance to microbicidal proteins from phagocytic cells
Science.
.
Abstract
Facultative intracellular pathogens pose an important health problem because they circumvent a primary defense mechanism of the host: killing and degradation by professional phagocytic cells. A gene of the intracellular pathogen Salmonella typhimurium that is required for virulence and intracellular survival was identified and shown to have a role in resistance to defensins and possibly to other microbicidal mechanisms of the phagocyte. This gene may prove to be a regulatory element in the expression of virulence functions.
Similar articles
-
Resistance to host antimicrobial peptides is necessary for Salmonella virulence.Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):11939-43. doi: 10.1073/pnas.89.24.11939. Proc Natl Acad Sci U S A. 1992. PMID: 1465423 Free PMC article.
-
Salmonella typhimurium phoP virulence gene is a transcriptional regulator.Proc Natl Acad Sci U S A. 1989 Sep;86(18):7077-81. doi: 10.1073/pnas.86.18.7077. Proc Natl Acad Sci U S A. 1989. PMID: 2674945 Free PMC article.
-
Mutants of Salmonella typhimurium that cannot survive within the macrophage are avirulent.Proc Natl Acad Sci U S A. 1986 Jul;83(14):5189-93. doi: 10.1073/pnas.83.14.5189. Proc Natl Acad Sci U S A. 1986. PMID: 3523484 Free PMC article.
-
The ins and outs of virulence gene expression: Mg2+ as a regulatory signal.Bioessays. 1998 Jan;20(1):96-101. doi: 10.1002/(SICI)1521-1878(199801)20:1<96::AID-BIES13>3.0.CO;2-3. Bioessays. 1998. PMID: 9504051 Review.
-
Oxygen-dependent and oxygen-independent mechanisms of microbicidal activity of neutrophils.Immunol Lett. 1985;11(3-4):159-63. doi: 10.1016/0165-2478(85)90163-4. Immunol Lett. 1985. PMID: 3910565 Review.
Cited by
-
Acidic pH and divalent cation sensing by PhoQ are dispensable for systemic salmonellae virulence.Elife. 2015 May 23;4:e06792. doi: 10.7554/eLife.06792. Elife. 2015. PMID: 26002083 Free PMC article.
-
A connecter-like factor, CacA, links RssB/RpoS and the CpxR/CpxA two-component system in Salmonella.BMC Microbiol. 2012 Oct 2;12:224. doi: 10.1186/1471-2180-12-224. BMC Microbiol. 2012. PMID: 23031642 Free PMC article.
-
Expression, purification, crystallization and preliminary X-ray analysis of the extracellular sensory domain of DraK histidine kinase from Streptomyces coelicolor.Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Aug;69(Pt 8):909-11. doi: 10.1107/S1744309113018769. Epub 2013 Jul 27. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013. PMID: 23908041 Free PMC article.
-
Molecular and functional characterization of the Salmonella invasion gene invA: homology of InvA to members of a new protein family.J Bacteriol. 1992 Jul;174(13):4338-49. doi: 10.1128/jb.174.13.4338-4349.1992. J Bacteriol. 1992. PMID: 1624429 Free PMC article.
-
Environmental signals controlling expression of virulence determinants in bacteria.J Bacteriol. 1992 Jan;174(1):1-7. doi: 10.1128/jb.174.1.1-7.1992. J Bacteriol. 1992. PMID: 1729202 Free PMC article. Review. No abstract available.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
