Building the foundation for genomics in precision medicine

Nature. 2015 Oct 15;526(7573):336-42. doi: 10.1038/nature15816.


Precision medicine has the potential to profoundly improve the practice of medicine. However, the advances required will take time to implement. Genetics is already being used to direct clinical decision-making and its contribution is likely to increase. To accelerate these advances, fundamental changes are needed in the infrastructure and mechanisms for data collection, storage and sharing. This will create a continuously learning health-care system with seamless cycling between clinical care and research. Patients must be educated about the benefits of sharing data. The building blocks for such a system are already forming and they will accelerate the adoption of precision medicine.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Attitude of Health Personnel
  • Clinical Laboratory Services
  • Electronic Health Records
  • Genetics, Medical / organization & administration
  • Genetics, Medical / trends
  • Genomics / organization & administration*
  • Genomics / trends*
  • Humans
  • Patients
  • Physicians
  • Precision Medicine / methods*
  • Precision Medicine / trends*
  • Research Personnel