Pharmacogenomics in the clinic

Nature. 2015 Oct 15;526(7573):343-50. doi: 10.1038/nature15817.


After decades of discovery, inherited variations have been identified in approximately 20 genes that affect about 80 medications and are actionable in the clinic. And some somatically acquired genetic variants direct the choice of 'targeted' anticancer drugs for individual patients. Current efforts that focus on the processes required to appropriately act on pharmacogenomic variability in the clinic are moving away from discovery and towards implementation of an evidenced-based strategy for improving the use of medications, thereby providing a cornerstone for precision medicine.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Evidence-Based Medicine / methods
  • Evidence-Based Medicine / trends
  • Genetic Testing / trends
  • Genetic Variation / drug effects*
  • Genetic Variation / genetics*
  • Humans
  • Neoplasms / drug therapy
  • Neoplasms / genetics
  • Neoplasms / pathology
  • Pharmacogenetics / methods*
  • Pharmacogenetics / trends*
  • Precision Medicine / methods*
  • Precision Medicine / trends*