A Compressive Sensing Approach for 3D Breast Cancer Microwave Imaging With Magnetic Nanoparticles as Contrast Agent

IEEE Trans Med Imaging. 2016 Feb;35(2):665-73. doi: 10.1109/TMI.2015.2490340. Epub 2015 Oct 13.

Abstract

In microwave breast cancer imaging magnetic nanoparticles have been recently proposed as contrast agent. Due to the non-magnetic nature of human tissues, magnetic nanoparticles make possible the overcoming of some limitations of conventional microwave imaging techniques, thus providing reliable and specific diagnosis of breast cancer. In this paper, a Compressive Sensing inspired inversion technique is introduced for the reconstruction of the magnetic contrast induced within the tumor. The applicability of Compressive Sensing theory is guaranteed by the fact that the underlying inverse scattering problem is linear and the searched magnetic perturbation is sparse. From the numerical analysis, performed in realistic conditions in 3D geometry, it has been pointed out that the adoption of this new tool allows improving resolution and accuracy of the reconstructions, as well as reducing the number of required measurements.

MeSH terms

  • Algorithms
  • Breast / diagnostic imaging
  • Breast Neoplasms / diagnostic imaging*
  • Contrast Media / chemistry*
  • Contrast Media / therapeutic use
  • Female
  • Humans
  • Imaging, Three-Dimensional / methods*
  • Magnetite Nanoparticles / chemistry*
  • Magnetite Nanoparticles / therapeutic use
  • Microwaves / therapeutic use*
  • Phantoms, Imaging

Substances

  • Contrast Media
  • Magnetite Nanoparticles