Factors Associated with Anxiety and Depression in Korean Patients with Inactive Inflammatory Bowel Disease

Gut Liver. 2016 May 23;10(3):399-405. doi: 10.5009/gnl15188.


Background/aims: Psychological distress is highly prevalent in patients with inflammatory bowel disease (IBD). We evaluated the disease characteristics and socioeconomic factors associated with anxiety and depression in Korean patients with quiescent IBD.

Methods: In total, 142 IBD patients (67 with Crohn's disease [CD] and 75 with ulcerative colitis [UC]) completed self-report questionnaires, including the Hospital Anxiety and Depression Score, the Modified Morisky Adherence Scale-8, the socioeconomic deprivation score, and the Crohn's and Colitis Knowledge Score questionnaires.

Results: In the CD group, 30 patients (44%) were anxious, and 10 patients (15%) were depressed; in the UC group, 31 patients (41%) were anxious, and 18 patients (24%) were depressed. Using multivariate analysis, in the CD group, socioeconomic deprivation was associated with anxiety (p=0.03), whereas disease duration (p=0.04) and socioeconomic deprivation (p=0.013) were associated with depression. In the UC group, there was no significant independent predictor of anxiety and/or depression; however, low income tended to be associated with depression (p=0.096).

Conclusions: Despite clinical remission, a significant number of IBD patients present with anxiety and depression. IBD patients in remission, particularly those who are socioeconomically deprived, should be provided with appropriate psychological support.

Keywords: Anxiety; Depression; Inflammatory bowel diseases.

MeSH terms

  • Adult
  • Anxiety Disorders / ethnology
  • Anxiety Disorders / etiology*
  • Case-Control Studies
  • Colitis, Ulcerative / ethnology
  • Colitis, Ulcerative / psychology*
  • Crohn Disease / ethnology
  • Crohn Disease / psychology*
  • Depressive Disorder / ethnology
  • Depressive Disorder / etiology*
  • Female
  • Humans
  • Income
  • Male
  • Republic of Korea / ethnology
  • Socioeconomic Factors
  • Surveys and Questionnaires