Innate lymphoid cells in inflammatory bowel diseases
- PMID: 26470815
- DOI: 10.1016/j.imlet.2015.10.004
Innate lymphoid cells in inflammatory bowel diseases
Abstract
It is generally believed that inflammatory bowel diseases (IBD) are caused by an aberrant immune response to environmental triggers in genetically susceptible individuals. The exact contribution of the adaptive and innate immune system has not been elucidated. However, recent advances in treatments targeting key inflammatory mediators such as tumour necrosis factor highlight the crucial role of the innate immune system in IBD. Innate lymphoid cells (ILCs) have recently been identified to play an important role in immune mediated inflammatory diseases. In this review we recapitulate the current knowledge on ILCs in IBD.
Keywords: Anti-TNF; Crohn’s disease; IBD; IFN-γ; ILC; Innate lymphoid cells; Ulcerative colitis.
Copyright © 2015 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.
Similar articles
-
Innate and adaptive immunity in inflammatory bowel disease.Autoimmun Rev. 2014 Jan;13(1):3-10. doi: 10.1016/j.autrev.2013.06.004. Epub 2013 Jun 15. Autoimmun Rev. 2014. PMID: 23774107 Review.
-
Innate Lymphoid Cells in Inflammatory Bowel Disease.Arch Immunol Ther Exp (Warsz). 2018 Dec;66(6):415-421. doi: 10.1007/s00005-018-0519-5. Epub 2018 Aug 29. Arch Immunol Ther Exp (Warsz). 2018. PMID: 30155762 Review.
-
Innate Lymphoid Cells in Intestinal Homeostasis and Inflammatory Bowel Disease.Int J Mol Sci. 2021 Jul 16;22(14):7618. doi: 10.3390/ijms22147618. Int J Mol Sci. 2021. PMID: 34299236 Free PMC article. Review.
-
Immunotherapy in inflammatory bowel disease: Novel and emerging treatments.Hum Vaccin Immunother. 2018;14(11):2597-2611. doi: 10.1080/21645515.2018.1461297. Epub 2018 May 22. Hum Vaccin Immunother. 2018. PMID: 29624476 Free PMC article.
-
The unusual suspects--innate lymphoid cells as novel therapeutic targets in IBD.Nat Rev Gastroenterol Hepatol. 2015 May;12(5):271-83. doi: 10.1038/nrgastro.2015.52. Nat Rev Gastroenterol Hepatol. 2015. PMID: 25971811 Review.
Cited by
-
Controversial role of ILC3s in intestinal diseases: A novelty perspective on immunotherapy.Front Immunol. 2023 Mar 28;14:1134636. doi: 10.3389/fimmu.2023.1134636. eCollection 2023. Front Immunol. 2023. PMID: 37063879 Free PMC article. Review.
-
The Roles of Innate Lymphoid Cells in the Gastric Mucosal Immunology and Oncogenesis of Gastric Cancer.Int J Mol Sci. 2023 Apr 2;24(7):6652. doi: 10.3390/ijms24076652. Int J Mol Sci. 2023. PMID: 37047625 Free PMC article. Review.
-
Interplay between Serotonin, Immune Response, and Intestinal Dysbiosis in Inflammatory Bowel Disease.Int J Mol Sci. 2022 Dec 9;23(24):15632. doi: 10.3390/ijms232415632. Int J Mol Sci. 2022. PMID: 36555276 Free PMC article. Review.
-
Deciphering the role of autophagy in the immunopathogenesis of inflammatory bowel disease.Front Pharmacol. 2022 Nov 14;13:1070184. doi: 10.3389/fphar.2022.1070184. eCollection 2022. Front Pharmacol. 2022. PMID: 36452236 Free PMC article. Review.
-
Human innate lymphoid cell activation by adenoviruses is modified by host defense proteins and neutralizing antibodies.Front Immunol. 2022 Oct 5;13:975910. doi: 10.3389/fimmu.2022.975910. eCollection 2022. Front Immunol. 2022. PMID: 36275713 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
