Prevention of increased abnormal fundus autofluorescence with blue light-filtering intraocular lenses

J Cataract Refract Surg. 2015 Sep;41(9):1855-9. doi: 10.1016/j.jcrs.2015.01.017. Epub 2015 Oct 23.


Purpose: To observe changes in fundus autofluorescence 2 years after implantation of blue light-filtering (yellow-tinted) and ultraviolet light-filtering (colorless) intraocular lenses (IOLs).

Setting: Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, and the Department of Ophthalmology, University of Bern, Bern, Switzerland.

Design: Prospective comparative observational study.

Methods: Patients were enrolled who had cataract surgery with implantation of a yellow-tinted or colorless IOL and for whom images were obtained on which the fundus autofluorescence was measurable using the Heidelberg Retina Angiogram 2 postoperatively. The fundus autofluorescence in the images was classified into 8 abnormal patterns based on the classification of the International Fundus Autofluorescence Classification Group, The presence of normal fundus autofluorescence, geographic atrophy, and wet age-related macular degeneration (AMD) also was recorded. The fundus findings at baseline and 2 years postoperatively were compared.

Results: Fifty-two eyes with a yellow-tinted IOL and 79 eyes with a colorless IOL were included. Abnormal fundus autofluorescence did not develop or increase in the yellow-tinted IOL group; however, progressive abnormal fundus autofluorescence developed or increased in 12 eyes (15.2%) in the colorless IOL group (P = .0016). New drusen, geographic atrophy, and choroidal neovascularization were observed mainly in the colorless IOL group. The incidence of AMD was statistically significantly higher in the colorless IOL group (P = .042).

Conclusions: Two years after cataract surgery, significant differences were seen in the progression of abnormal fundus autofluorescence between the 2 groups. The incidence of AMD was lower in eyes with a yellow-tinted IOL.

Financial disclosure: No author has a financial or proprietary interest in any material or method mentioned.

Publication types

  • Comparative Study
  • Multicenter Study
  • Observational Study

MeSH terms

  • Aged
  • Aged, 80 and over
  • Female
  • Filtration / instrumentation*
  • Fundus Oculi
  • Humans
  • Lens Implantation, Intraocular*
  • Lenses, Intraocular*
  • Macular Degeneration / diagnosis
  • Macular Degeneration / etiology
  • Macular Degeneration / prevention & control*
  • Male
  • Middle Aged
  • Optical Imaging
  • Phacoemulsification*
  • Prospective Studies
  • Prosthesis Design
  • Radiation Injuries / diagnosis
  • Radiation Injuries / etiology
  • Radiation Injuries / prevention & control*
  • Retina / radiation effects*
  • Ultraviolet Rays / adverse effects