Ineffective erythropoiesis caused by binucleated late-stage erythroblasts in mDia2 hematopoietic specific knockout mice

Haematologica. 2016 Jan;101(1):e1-5. doi: 10.3324/haematol.2015.134221. Epub 2015 Oct 15.

Authors

Yang Mei¹, Baobing Zhao¹, Jing Yang¹, Juehua Gao¹, Amittha Wickrema², Dehua Wang³, Yihua Chen¹, Peng Ji⁴

Affiliations

¹ Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
² Section of Hematology/Oncology, Department of Medicine, The University of Chicago, IL, USA.
³ Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, OH, USA.
⁴ Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA ji.peng@northwestern.edu.

No abstract available

Keywords: cytokinesis; enucleation; erythropoiesis; knockout mice; mDia2.

Publication types

Letter

MeSH terms

Animals
Cell Nucleus / genetics
Cell Nucleus / metabolism*
Cell Nucleus / pathology
Erythroblasts / metabolism*
Erythroblasts / pathology
Erythropoiesis*
Mice
Mice, Knockout
Microtubule-Associated Proteins / deficiency*
NADPH Dehydrogenase / deficiency*
rac GTP-Binding Proteins / genetics
rac GTP-Binding Proteins / metabolism

Substances

Microtubule-Associated Proteins
Dia2 protein, mouse
NADPH Dehydrogenase
rac GTP-Binding Proteins

Grants and funding