Multiparametric magnetic resonance imaging predicts clinical outcomes in patients with chronic liver disease

J Hepatol. 2016 Feb;64(2):308-315. doi: 10.1016/j.jhep.2015.10.009. Epub 2015 Nov 10.


Background & aims: Multiparametric magnetic resonance (MR) imaging has been demonstrated to quantify hepatic fibrosis, iron, and steatosis. The aim of this study was to determine if MR can be used to predict negative clinical outcomes in liver disease patients.

Methods: Patients with chronic liver disease (n=112) were recruited for MR imaging and data on the development of liver related clinical events were collected by medical records review. The median follow-up was 27months. MR data were analysed blinded for the Liver Inflammation and Fibrosis score (LIF; <1, 1-1.99, 2-2.99, and ⩾3 representing normal, mild, moderate, and severe liver disease, respectively), T2∗ for liver iron content and proportion of liver fat. Baseline liver biopsy was performed in 102 patients.

Results: Liver disease aetiologies included non-alcoholic fatty liver disease (35%) and chronic viral hepatitis (30%). Histologically, fibrosis was mild in 54 (48%), moderate in 17 (15%), and severe in 31 (28%) patients. Overall mortality was 5%. Ten patients (11%) developed at least one liver related clinical event. The negative predictive value of LIF<2 was 100%. Two patients with LIF 2-2.99 and eight with LIF⩾3 had a clinical event. Patients with LIF⩾3 had a higher cumulative risk for developing clinical events, compared to those with LIF<1 (p=0.02) and LIF 1-1.99 (p=0.03). Cox regression analysis including all 3 variables (fat, iron, LIF) resulted in an enhanced LIF predictive value.

Conclusions: Non-invasive standardised multiparametric MR technology may be used to predict clinical outcomes in patients with chronic liver disease.

Keywords: Iron corrected T(1); LIF score; LiverMultiScan; T(1) mapping.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biopsy
  • Female
  • Fibrosis / diagnostic imaging
  • Fibrosis / pathology
  • Hepatitis, Chronic* / diagnostic imaging
  • Hepatitis, Chronic* / mortality
  • Hepatitis, Chronic* / pathology
  • Hepatitis, Chronic* / virology
  • Humans
  • Inflammation / diagnostic imaging
  • Inflammation / pathology
  • Kaplan-Meier Estimate
  • Liver* / diagnostic imaging
  • Liver* / pathology
  • Magnetic Resonance Imaging / methods*
  • Male
  • Middle Aged
  • Non-alcoholic Fatty Liver Disease* / diagnostic imaging
  • Non-alcoholic Fatty Liver Disease* / mortality
  • Non-alcoholic Fatty Liver Disease* / pathology
  • Predictive Value of Tests
  • Prognosis
  • Risk Assessment
  • Severity of Illness Index
  • United Kingdom / epidemiology