Transition-Metal-Free Oxyfluorination of Olefinic Amides for the Synthesis of Fluorinated Heterocycles

J Org Chem. 2015 Nov 6;80(21):11149-55. doi: 10.1021/acs.joc.5b01909. Epub 2015 Oct 28.

Abstract

A series of fluorinated 4H-3,1-benzoxazines and iminoisobenzofurans have been synthesized through the electrophilic fluorocyclization of olefinic amides. This methodology is highlighted by its mild conditions, wide substrate scope, and good functional group tolerance.

Publication types

  • Research Support, Non-U.S. Gov't