Prognostic significance of Ki-67 reactivity in soft tissue sarcomas

Cancer. 1989 Apr 15;63(8):1607-11. doi: 10.1002/1097-0142(19890415)63:8<1607::aid-cncr2820630827>;2-1.


Proliferative activity of soft tissue sarcomas (STS) in 34 cases was estimated by immunohistochemical procedures (avidin-biotin complex [ABC] method) with monoclonal antibody Ki-67 which reacts with a nuclear antigen expressed in all phases of cell cycle except G0. In 20 of 34 cases (59%), varying numbers of Ki-67-positive tumor cells were detected with a range from 5 to 382 per 10 high power fields (HPF) (mean 57.2/10 HPF). Ki-67 index (the number of Ki-67-positive tumor cells/10 HPF) positively correlated with mitotic count (r = 0.428, P less than 0.02), cellularity (r = 0.447, P less than 0.01), and histologic grade (r = 0.473, P less than 0.01). The Ki-67 low index group (less than 50/10 HPF) showed more favorable prognosis than the high index group (more than 50/10 HPF) (P less than 0.005). Three cases with low mitotic count and unfavorable prognosis were proved to be the Ki-67 high index group (142-382/10 HPF). These results indicated that reactivity of tumor cells for Ki-67 is a useful prognostic marker in the patients with STS, and might be used as one of the histologic factors for the grading of STS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antibodies, Monoclonal*
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Male
  • Middle Aged
  • Nuclear Proteins / analysis*
  • Prognosis
  • Sarcoma / analysis
  • Sarcoma / mortality
  • Sarcoma / pathology*
  • Soft Tissue Neoplasms / analysis
  • Soft Tissue Neoplasms / mortality
  • Soft Tissue Neoplasms / pathology*


  • Antibodies, Monoclonal
  • Nuclear Proteins