Biology of Regional Body Fat Distribution: Relationship to Non-Insulin-Dependent Diabetes Mellitus

Diabetes Metab Rev. 1989 Mar;5(2):83-109. doi: 10.1002/dmr.5610050202.

Abstract

Our studies support the view that body fat distribution and the accompanying metabolic abnormalities could be exacerabated by variability in the androgenic/estrogenic balance. Sensitivity to the androgenic milieu might be initiated by an early developmental aberration in sexual dimorphism. The possible direct and indirect sites of interaction between androgenic activity and the abnormal metabolic pathways in upper body obesity are summarized in Figure 19.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adipose Tissue / metabolism
  • Adipose Tissue / physiopathology*
  • Androgens / metabolism
  • Blood Pressure
  • Diabetes Mellitus / etiology
  • Diabetes Mellitus / metabolism
  • Diabetes Mellitus / pathology
  • Diabetes Mellitus, Type 2 / complications
  • Diabetes Mellitus, Type 2 / metabolism
  • Diabetes Mellitus, Type 2 / pathology*
  • Estrogens / metabolism
  • Female
  • Glucose / physiology
  • Homeostasis
  • Humans
  • Insulin / physiology
  • Lipoproteins / metabolism
  • Metabolic Diseases / metabolism
  • Metabolic Diseases / physiopathology
  • Obesity

Substances

  • Androgens
  • Estrogens
  • Insulin
  • Lipoproteins
  • Glucose