IL-17 Induces Fetal Loss in a CBA/J×BALB/c Mouse Model, and an Anti-IL-17 Antibody Prevents Fetal Loss in a CBA/J×DBA/2 Mouse Model
- PMID: 26474535
- DOI: 10.1111/aji.12437
IL-17 Induces Fetal Loss in a CBA/J×BALB/c Mouse Model, and an Anti-IL-17 Antibody Prevents Fetal Loss in a CBA/J×DBA/2 Mouse Model
Abstract
Problem: Many researchers have demonstrated that the expression of interleukin-17(IL-17) is higher in spontaneous abortion. However, whether Th17 cells are an independent factor in inducing abortion is not known.
Method of study: This study investigated the effect of exogenous recombinant IL-17 and an anti-IL-17 antibody in a normal and an abortion mouse model using flow cytometry, enzyme-linked immunosorbent assay, real-time PCR, and Western blot.
Results: Th17 cells and the related factors, IL-17 and RORγt, were significantly upregulated in abortion mice, and Treg cells and the related factor, Foxp3, were downregulated. Intraperitoneal injection of recombinant IL (rIL)-17 induced fetal loss in a normal mouse model, and an anti-IL-17 antibody prevented fetal loss in an abortion mouse model.
Conclusion: This study confirmed an imbalance of the Th17/Treg paradigm in abortion mice and IL-17 as a risk factor of fetal loss. An anti-IL-17 antibody may prevent abortion.
Keywords: Abortion; antibody; interleukin-17; regulatory T cells.
© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Similar articles
-
Adoptive transfer of pregnancy-induced CD4+CD25+ regulatory T cells reverses the increase in abortion rate caused by interleukin 17 in the CBA/JxBALB/c mouse model.Hum Reprod. 2014 May;29(5):946-52. doi: 10.1093/humrep/deu014. Epub 2014 Feb 20. Hum Reprod. 2014. PMID: 24556316
-
The Treg/Th17 imbalance in Toxoplasma gondii-infected pregnant mice.Am J Reprod Immunol. 2012 Feb;67(2):112-21. doi: 10.1111/j.1600-0897.2011.01065.x. Epub 2011 Sep 19. Am J Reprod Immunol. 2012. PMID: 21923716
-
Recombinant adiponectin alleviates abortion in mice by regulating Th17/Treg imbalance via p38MAPK-STAT5 pathway.Biol Reprod. 2019 Apr 1;100(4):1008-1017. doi: 10.1093/biolre/ioy251. Biol Reprod. 2019. PMID: 30496353
-
FOXP3 and RORγt: transcriptional regulation of Treg and Th17.Int Immunopharmacol. 2011 May;11(5):536-42. doi: 10.1016/j.intimp.2010.11.008. Epub 2010 Nov 23. Int Immunopharmacol. 2011. PMID: 21081189 Review.
-
Are both endogenous and exogenous factors involved in spontaneous foetal abortion?Res Immunol. 1990 Feb;141(2):154-8. doi: 10.1016/0923-2494(90)90135-l. Res Immunol. 1990. PMID: 2202028 Review. No abstract available.
Cited by
-
Regulatory T cell adoptive transfer alters uterine immune populations, increasing a novel MHC-IIlow macrophage associated with healthy pregnancy.Front Immunol. 2023 Oct 13;14:1256453. doi: 10.3389/fimmu.2023.1256453. eCollection 2023. Front Immunol. 2023. PMID: 37901247 Free PMC article.
-
Hyperin promotes proliferation, migration, and invasion of HTR-8/SVneo trophoblast cells via activation of JAK1/STAT3 pathway in recurrent spontaneous abortions.Heliyon. 2023 Jan 13;9(1):e12958. doi: 10.1016/j.heliyon.2023.e12958. eCollection 2023 Jan. Heliyon. 2023. PMID: 36747955 Free PMC article.
-
The Update Immune-Regulatory Role of Pro- and Anti-Inflammatory Cytokines in Recurrent Pregnancy Losses.Int J Mol Sci. 2022 Dec 21;24(1):132. doi: 10.3390/ijms24010132. Int J Mol Sci. 2022. PMID: 36613575 Free PMC article. Review.
-
Human chorionic gonadotropin promotes murine Treg cells and restricts pregnancy-harmful proinflammatory Th17 responses.Front Immunol. 2022 Sep 20;13:989247. doi: 10.3389/fimmu.2022.989247. eCollection 2022. Front Immunol. 2022. PMID: 36203576 Free PMC article.
-
Progesterone: A Unique Hormone with Immunomodulatory Roles in Pregnancy.Int J Mol Sci. 2022 Jan 25;23(3):1333. doi: 10.3390/ijms23031333. Int J Mol Sci. 2022. PMID: 35163255 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
