This article reviews the literature pertaining to the psychosocial adaptation of adolescents with cystic fibrosis. This chronic debilitating illness is exceptionally stressful to the patient and his or her family. It may result in significant individual and family psychopathology, yet social adaptation is reported to be remarkably good. Mediating variables in adaptation are reviewed, with special emphasis on family function variables. Directions for current interventions and future research are suggested. An expanded role for psychologic intervention with individual patients and their families is recommended.