Use of ketoconazole in the treatment of canine nasal aspergillosis

J Am Vet Med Assoc. 1989 Mar 15;194(6):782-6.


Fifteen dogs with nasal aspergillosis were treated with ketoconazole (5 mg/kg of body weight, q 12 h, PO) for 2 to 18 weeks. Four dogs whose conditions deteriorated during treatment received ketoconazole for less than the prescribed 6 weeks. Six months or more later, only 47% of the dogs were determined to be disease-free, on the basis of no fungal growth on culture. It was concluded that ketoconazole at this dosage is a useful treatment for canine nasal aspergillosis, but is no more effective than thiabendazole.

MeSH terms

  • Animals
  • Aspergillosis / drug therapy
  • Aspergillosis / veterinary*
  • Aspergillus fumigatus
  • Dog Diseases / drug therapy*
  • Dogs
  • Dose-Response Relationship, Drug
  • Ketoconazole / therapeutic use*
  • Nose Diseases / drug therapy
  • Nose Diseases / veterinary*
  • Thiabendazole / therapeutic use


  • Thiabendazole
  • Ketoconazole