Spinal cord involvement in Behçet's disease

Mult Scler. 2016 Jun;22(7):960-3. doi: 10.1177/1352458515613642. Epub 2015 Oct 19.


Background: Spinal cord involvement in Behçet's disease is not well studied.

Objective: To evaluate the clinical, laboratory and magnetic resonance imaging characteristics of spinal cord involvement in Behçet's disease.

Methods: We retrospectively reviewed 10 spinal cord involvements in seven patients with Behçet's disease.

Results: The median age of onset for spinal cord involvement was 32 (23-45 years). Two patients showed a secondary progressive course. Cerebrospinal fluid findings revealed mild to moderate pleocytosis and/or elevated protein levels. In eight spinal cord involvements, the lesion was longer than three vertebrae. Serum anti-aquaporin-4 antibody was negative in all four patients tested.

Conclusions: Longitudinally extensive transverse myelitis is a characteristic manifestation of spinal cord involvement in Behçet's disease.

Keywords: Behçet’s disease; longitudinally extensive transverse myelitis; neuro-Behçet’s disease; neuromyelitis optica; serum anti-aquaporin-4 antibody; spinal cord.

MeSH terms

  • Adult
  • Behcet Syndrome / complications*
  • Behcet Syndrome / diagnostic imaging
  • Biomarkers / cerebrospinal fluid
  • Disability Evaluation
  • Disease Progression
  • Female
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Myelitis, Transverse / cerebrospinal fluid
  • Myelitis, Transverse / diagnostic imaging
  • Myelitis, Transverse / drug therapy
  • Myelitis, Transverse / etiology*
  • Registries
  • Retrospective Studies
  • Spinal Cord* / diagnostic imaging
  • Spinal Cord* / drug effects
  • Spinal Cord* / metabolism
  • Treatment Outcome
  • Young Adult


  • Biomarkers
  • Immunosuppressive Agents