Periarrest intestinal bacterial translocation and resuscitation outcome

J Crit Care. 2016 Feb;31(1):217-20. doi: 10.1016/j.jcrc.2015.09.015. Epub 2015 Sep 25.

Abstract

During the periarrest period, intestinal ischemia may result in barrier dysfunction and bacterial translocation, which has clear mechanistic links to inflammation and cascade stimulation, especially in patients who are treated with therapeutic hypothermia. Despite optimal management, periarrest bacterial translocation may worsen the outcome of cardiac arrest victims.

Keywords: Bacterial translocation; Cardiac arrest; Cardiopulmonary resuscitation; Intestine; Ischemia.

MeSH terms

  • Bacteremia / immunology*
  • Bacterial Translocation*
  • Cardiopulmonary Resuscitation*
  • Heart Arrest / metabolism
  • Heart Arrest / therapy*
  • Humans
  • Hypothermia, Induced*
  • Inflammation
  • Intestinal Mucosa / metabolism*
  • Intestines / blood supply
  • Mesenteric Ischemia / metabolism*
  • Oxidative Stress