Human papillomavirus-associated neoplasms of the sinonasal tract and nasopharynx

Semin Diagn Pathol. 2016 Mar;33(2):104-11. doi: 10.1053/j.semdp.2015.09.011. Epub 2015 Sep 9.


It is now well established that human papillomavirus (HPV) is an important causative factor in a subgroup of head and neck cancer. In the head and neck, while HPV is strongly associated with squamous cell carcinoma arising in the oropharynx, there is a growing interest in HPV-associated neoplasms of non-oropharyngeal origin including those which arise within sinonasal and nasopharyngeal mucosa. This article reviews current literature on the association of HPV with Scheiderian papillomas, sinonasal squamous cell carcinoma, sinonasal undifferentiated carcinoma, carcinoma with adenoid cystic-like features, and nasopharyngeal carcinoma. Several clinical implications of HPV detection in sinonasal and nasopharyngeal carcinomas are briefly discussed.

Keywords: HPV; Human papillomavirus; nasopharyngeal; sinonasal.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor / analysis
  • Biopsy
  • DNA, Viral / genetics
  • Human Papillomavirus DNA Tests
  • Humans
  • Immunohistochemistry
  • Nasal Cavity / chemistry
  • Nasal Cavity / pathology
  • Nasal Cavity / virology*
  • Nose Neoplasms / chemistry
  • Nose Neoplasms / classification
  • Nose Neoplasms / pathology
  • Nose Neoplasms / virology*
  • Papillomaviridae / genetics
  • Papillomaviridae / isolation & purification*
  • Papillomavirus Infections / pathology
  • Papillomavirus Infections / virology*
  • Paranasal Sinus Neoplasms / chemistry
  • Paranasal Sinus Neoplasms / classification
  • Paranasal Sinus Neoplasms / pathology
  • Paranasal Sinus Neoplasms / virology*
  • Predictive Value of Tests
  • Risk Factors


  • Biomarkers, Tumor
  • DNA, Viral