HSFs, Stress Sensors and Sculptors of Transcription Compartments and Epigenetic Landscapes

Federico Miozzo; Délara Sabéran-Djoneidi; Valérie Mezger

doi:10.1016/j.jmb.2015.10.007

HSFs, Stress Sensors and Sculptors of Transcription Compartments and Epigenetic Landscapes

J Mol Biol. 2015 Dec 4;427(24):3793-816. doi: 10.1016/j.jmb.2015.10.007. Epub 2015 Oct 22.

Authors

Federico Miozzo¹, Délara Sabéran-Djoneidi², Valérie Mezger³

Affiliations

¹ UMR7216 Épigénétique et Destin Cellulaire, Centre National de la Recherche Scientifique, F-75205 Paris Cedex 13, France; Sorbonne Paris Cité, Université Paris Diderot Paris 7, F-75205 Paris Cedex 13, France; Départements Hospitalo Universitaires PROTECT, F-75019 Paris Cedex 13, France; ED 387 iViv, University Pierre et Marie Curie Paris 6 F-75252 Paris Cedex 05, France; ED 562 BioSPC, Université Paris Diderot Paris 7, F-75205 Paris Cedex 13, France.
² UMR7216 Épigénétique et Destin Cellulaire, Centre National de la Recherche Scientifique, F-75205 Paris Cedex 13, France; Sorbonne Paris Cité, Université Paris Diderot Paris 7, F-75205 Paris Cedex 13, France; Départements Hospitalo Universitaires PROTECT, F-75019 Paris Cedex 13, France.
³ UMR7216 Épigénétique et Destin Cellulaire, Centre National de la Recherche Scientifique, F-75205 Paris Cedex 13, France; Sorbonne Paris Cité, Université Paris Diderot Paris 7, F-75205 Paris Cedex 13, France; Départements Hospitalo Universitaires PROTECT, F-75019 Paris Cedex 13, France. Electronic address: valerie.mezger@univ-paris-diderot.fr.

PMID: 26482101
DOI: 10.1016/j.jmb.2015.10.007

Abstract

Starting as a paradigm for stress responses, the study of the transcription factor (TF) family of heat shock factors (HSFs) has quickly and widely expanded these last decades, thanks to their fascinating and significant involvement in a variety of pathophysiological processes, including development, reproduction, neurodegeneration and carcinogenesis. HSFs, originally defined as classical TFs, strikingly appeared to play a central and often pioneering role in reshaping the epigenetic landscape. In this review, we describe how HSFs are able to sense the epigenetic environment, and we review recent data that support their role as sculptors of the chromatin landscape through their complex interplay with chromatin remodelers, histone-modifying enzymes and non-coding RNAs.

Keywords: HSF; chromatin remodeling; epigenetics; stress responsive.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Base Sequence
Binding Sites
Epigenesis, Genetic*
Heat-Shock Proteins / physiology*
Humans
Stress, Physiological*
Transcription Factors / physiology*
Transcription, Genetic

Substances

Heat-Shock Proteins
Transcription Factors