Gene expression profile in the fat tissue of Fsp27 deficient mice

Li Xu; Xiayu Xia; Muhammad Arshad; Linkang Zhou

doi:10.1016/j.gdata.2015.07.003

Gene expression profile in the fat tissue of Fsp27 deficient mice

Genom Data. 2015 Jul 11:5:326-8. doi: 10.1016/j.gdata.2015.07.003. eCollection 2015 Sep.

Authors

Li Xu¹, Xiayu Xia², Muhammad Arshad³, Linkang Zhou⁴

Affiliations

¹ Key Laboratory for Feed Biotechnology of the Ministry of Agriculture, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
² Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences, Beijing 100021, China.
³ Department of Bioinformatics and Biotechnology, International Islamic University, Islamabad 44000, Pakistan.
⁴ Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.

Abstract

Fsp27 is a lipid droplet-associated protein almost exclusively expressed in adipocytes where it facilitates unilocular lipid droplet formation. In mice, Fsp27 deficiency is associated with increased basal lipolysis, browning of white fat and a healthy metabolic profile, whereas energetically challenged Fsp27 deficient mice (ob/ob/Fsp27 (-/-)) show dramatically reduced fat mass, hepatic steatosis and insulin resistance which represents a typical lipodystrophy phenotype. Here, we investigate the effect of Fsp27 depletion on the gene expression of gonadal white adipose tissue (GWAT) under normal or energetically challenged condition (Fsp27 (-/-) vs Wild type; ob/ob/Fsp27 (-/-) vs ob/ob). We systematically analyzed the change in signaling pathway in Fsp27 deficient mice. The raw data have been deposited into Gene Expression Omnibus (GEO): GSE59807 and GSE22693.

Keywords: Fat tissue; Fsp27; Microarray; Obesity.