Current Management of Eosinophilic Esophagitis 2015

J Clin Gastroenterol. 2016 Feb;50(2):99-110. doi: 10.1097/MCG.0000000000000430.

Abstract

Eosinophilic esophagitis (EoE) is a chronic inflammatory condition characterized by esophageal dysfunction and eosinophilic infiltrate (≥15/hpf) in the esophageal epithelium and the absence of other potential causes of eosinophilia. The prevalence is increasing and is the most common cause of solid food dysphagia in children and young adults. This article will review the diagnosis and management of EoE based on consensus conferences, systematic reviews, and meta-analysis and highlights seminal studies in our evolving treatment of this disease. However, all answers are not available and I will remark about the lessons learned in my clinical practice seeing EoE patients over the last 25 years. The complicated etiology of the complaint of dysphagia in EoE patients will be reviewed. The importance of utilizing endoscopy, biopsies, and barium esophagram to help define the 2 phenotypes (inflammatory, fibrostenosis) of EoE will be highlighted. The controversy about PPI-responsive esophageal eosinophilia will be discussed and contrasted with idiopathic EoE. Finally, the 3 treatment options for EoE (drugs, diet, dilation) will be reviewed in detail and a useful clinical management algorithm presented.

Publication types

  • Review

MeSH terms

  • Algorithms
  • Critical Pathways
  • Dilatation* / adverse effects
  • Eosinophilic Esophagitis / diagnosis
  • Eosinophilic Esophagitis / diet therapy
  • Eosinophilic Esophagitis / epidemiology
  • Eosinophilic Esophagitis / therapy*
  • Humans
  • Predictive Value of Tests
  • Proton Pump Inhibitors / adverse effects
  • Proton Pump Inhibitors / therapeutic use*
  • Risk Factors
  • Steroids / adverse effects
  • Steroids / therapeutic use*
  • Treatment Outcome

Substances

  • Proton Pump Inhibitors
  • Steroids