The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics

Curr Biol. 2015 Oct 19;25(20):R1002-18. doi: 10.1016/j.cub.2015.08.051.


The spindle assembly checkpoint is a safeguard mechanism that coordinates cell-cycle progression during mitosis with the state of chromosome attachment to the mitotic spindle. The checkpoint prevents mitotic cells from exiting mitosis in the presence of unattached or improperly attached chromosomes, thus avoiding whole-chromosome gains or losses and their detrimental effects on cell physiology. Here, I review a considerable body of recent progress in the elucidation of the molecular mechanisms underlying checkpoint signaling, and identify a number of unresolved questions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Eukaryotic Cells / physiology*
  • M Phase Cell Cycle Checkpoints*
  • Signal Transduction*
  • Spindle Apparatus / physiology*