Adv Exp Med Biol. 2016:880:339-62. doi: 10.1007/978-3-319-22536-4_19.


Thrombo-occlusive disease is a leading cause of morbidity and mortality. In this chapter, the use of ultrasound to accelerate clot breakdown alone or in combination with thrombolytic drugs will be reported. Primary thrombus formation during cardiovascular disease and standard treatment methods will be discussed. Mechanisms for ultrasound enhancement of thrombolysis, including thermal heating, radiation force, and cavitation, will be reviewed. Finally, in-vitro, in-vivo and clinical evidence of enhanced thrombolytic efficacy with ultrasound will be presented and discussed.

Keywords: Cardiovascular disease; Thrombus; Ultrasound.

Publication types

  • Review

MeSH terms

  • Cardiovascular Diseases / therapy*
  • Clinical Trials as Topic
  • Fibrinolytic Agents / therapeutic use*
  • Humans
  • Microbubbles
  • Ultrasonic Therapy*


  • Fibrinolytic Agents