Advances in the management of Barrett's esophagus and early esophageal adenocarcinoma

Gastroenterol Rep (Oxf). 2015 Nov;3(4):303-15. doi: 10.1093/gastro/gov048. Epub 2015 Oct 19.


The incidence of esophageal adenocarcinoma (EAC) has markedly increased in the United States over the last few decades. Barrett's esophagus (BE) is the most significant known risk factor for this malignancy. Theoretically, screening and treating early BE should help prevent EAC but the exact incidence of BE and its progression to EAC is not entirely known and cost-effectiveness studies for Barrett's screening are lacking. Over the last few years, there have been major advances in our understanding of the epidemiology, pathogenesis and endoscopic management of BE. These developments focus on early recognition of advanced histology and endoscopic treatment of high-grade dysplasia. Advanced resection techniques now enable us to endoscopically treat early esophageal cancer. In this review, we will discuss these recent advances in diagnosis and treatment of Barrett's esophagus and early esophageal adenocarcinoma.

Keywords: Barrett’s esophagus; early esophageal adenocarcinoma; endoscopy.

Publication types

  • Review