Keratin gel in the management of Epidermolysis bullosa

J Wound Care. 2015 Oct;24(10):446-50. doi: 10.12968/jowc.2015.24.10.446.


Objective: Epidermolysis bullosa (EB) describes a number of genetically inherited conditions which cause skin fragility and minor trauma leading to skin damage, skin loss and wounding. Owing to the fragility of the skin and requirement for frequent dressing changes, at present, the optimal dressing(s) is not clear. Our objective was to assess the use of a keratin gel in the management of wounds in patients with different forms of EB.

Method: We treated patients with different types of EB and a range of wounds with a novel keratin gel. In a convenience sample of consecutive patients, we introduced the keratin gel into their treatment regimen maintaining other aspects of their care.

Results: Patients reported faster healing and more resilient healed skin. Of the ten patients treated in this pilot study, six found the gel effective; two found it ineffective; and in two patients, it caused itching leading to discontinuation of the treatment.

Conclusion: The results of this case study series suggest that keratin gel can be useful in the management of EB and are consistent with previous published experiences.

Keywords: chronic wound; epidermolysis bullosa; keratin gel; skin fragility.

Publication types

  • Clinical Study
  • Comparative Study

MeSH terms

  • Adolescent
  • Bandages*
  • Child
  • Child, Preschool
  • Disease Management
  • Epidermolysis Bullosa / complications
  • Epidermolysis Bullosa / drug therapy*
  • Female
  • Gels / therapeutic use
  • Humans
  • Infant
  • Keratins / therapeutic use*
  • Male
  • Pilot Projects
  • Skin Abnormalities / drug therapy*
  • Skin Abnormalities / etiology
  • Treatment Outcome
  • Wound Healing / drug effects*


  • Gels
  • Keratins