Treatment of pressure ulcers in patients with declining renal function using arginine, glutamine and ß-hydroxy-ß-methylbutyrate

J Wound Care. 2015 Oct;24(10):478-82. doi: 10.12968/jowc.2015.24.10.478.


The aim of this study is to examine the efficacy on healing pressure ulcers (PU) of using a supplement combination containing arginine, glutamine and ß-hydroxy-ß-methylbutyrate, which was given to two elderly patients with renal dysfunction. The PU was surgically opened, decompressed and treated by drugs. A half quantity of the defined dose of the supplement combination, with an enteral nutrition product, was administered to the patients twice a day. This combination improved the PUs, with no effect on renal function. This novel finding may provide a nutritional rationale of arginine, glutamine and ß-hydroxy-ß-methylbutyrate for PUs associated with renal dysfunction.

Keywords: arginine; glutamine; pressure ulcer; renal dysfunction; ß-hydroxy-ß-methylbutyrate (HMB).

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Arginine / therapeutic use*
  • Dietary Supplements
  • Female
  • Food, Fortified*
  • Glutamine / therapeutic use*
  • Humans
  • Kidney Failure, Chronic / complications*
  • Pressure Ulcer / complications
  • Pressure Ulcer / diet therapy*
  • Treatment Outcome
  • Valerates / therapeutic use*
  • Wound Healing*


  • Valerates
  • Glutamine
  • beta-hydroxyisovaleric acid
  • Arginine