Abstract
Hitherto unknown 3,3'-carbonyl-bis(chromones) 8, dimeric chromones bridged by a carbonyl group, were prepared by reaction of chromone-3-carboxylic acid chloride with 3-(dimethylamino)-1- (2-hydroxyphenyl)-2-propen-1-ones 9. The method is generally applicable for the synthesis of novel symmetrical or non-symmetrical products which were found to inhibit mammalian alkaline phosphatases.
MeSH terms
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Alkaline Phosphatase / antagonists & inhibitors*
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Alkaline Phosphatase / metabolism
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Animals
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Cattle
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Chromones / chemical synthesis*
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Chromones / chemistry
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Chromones / pharmacology*
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Crystallography, X-Ray
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Dose-Response Relationship, Drug
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Intestines / enzymology
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Kidney / enzymology
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Models, Molecular
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Molecular Structure
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Structure-Activity Relationship
Substances
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Chromones
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Alkaline Phosphatase