Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 4 (vIRF4) Perturbs the G1-S Cell Cycle Progression via Deregulation of the Cyclin D1 Gene

J Virol. 2015 Oct 21;90(2):1139-43. doi: 10.1128/JVI.01897-15. Print 2016 Jan 15.

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV) infection modulates the host cell cycle to create an environment optimal for its viral-DNA replication during the lytic life cycle. We report here that KSHV vIRF4 targets the β-catenin/CBP cofactor and blocks its occupancy on the cyclin D1 promoter, suppressing the G1-S cell cycle progression and enhancing KSHV replication. This shows that KSHV vIRF4 suppresses host G1-S transition, possibly providing an intracellular milieu favorable for its replication.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Cycle Checkpoints*
  • Down-Regulation
  • Genes, bcl-1*
  • Herpesvirus 8, Human / physiology*
  • Host-Pathogen Interactions*
  • Interferon Regulatory Factors / metabolism*
  • Peptide Fragments / antagonists & inhibitors*
  • Sialoglycoproteins / antagonists & inhibitors*
  • Viral Proteins / metabolism*
  • Virus Replication
  • beta Catenin / antagonists & inhibitors*

Substances

  • CTNNB1 protein, human
  • Interferon Regulatory Factors
  • Peptide Fragments
  • Sialoglycoproteins
  • Viral Proteins
  • beta Catenin
  • bone sialoprotein (35-62), human
  • viral interferon regulatory factors