Identification of the target platelet glycoprotein in autoimmune thrombocytopenia occurring after allogeneic bone marrow transplantation

H Benda; S Panzer; V Kiefel; C Mannhalter; W Hinterberger; K Lechner; C Mueller-Eckhardt

doi:10.1007/BF00320436

Identification of the target platelet glycoprotein in autoimmune thrombocytopenia occurring after allogeneic bone marrow transplantation

Blut. 1989 Mar;58(3):151-3. doi: 10.1007/BF00320436.

Authors

H Benda¹, S Panzer, V Kiefel, C Mannhalter, W Hinterberger, K Lechner, C Mueller-Eckhardt

Affiliation

¹ Division of Hematology and Blood Coagulation, University of Vienna, Austria.

PMID: 2649188
DOI: 10.1007/BF00320436

Abstract

We report the case of a patient who developed autoimmune thrombocytopenia after allogeneic bone marrow transplantation from her HLA-identical sister. An IgG autoantibody was detected that bound to the platelet glycoprotein IIb/IIIa and to the HLA class I proteins. Immunoprecipitation studies with radiolabeled platelets revealed additional antibody binding sites on proteins of 214 kDa molecular weight under nonreduced conditions and 65 and 56 kDa molecular weight under reduced conditions.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Antilymphocyte Serum / analysis
Autoimmune Diseases / blood*
Autoimmune Diseases / etiology
Blood Platelets / analysis
Blood Platelets / immunology
Bone Marrow Transplantation*
Female
Humans
Platelet Membrane Glycoproteins / analysis*
Platelet Membrane Glycoproteins / immunology
Postoperative Complications / blood
Postoperative Complications / etiology
Thrombocytopenia / blood*
Thrombocytopenia / etiology

Substances

Antilymphocyte Serum
Platelet Membrane Glycoproteins