Metabolic Signaling to Chromatin

Cold Spring Harb Perspect Biol. 2016 Nov 1;8(11):a019463. doi: 10.1101/cshperspect.a019463.


There is a dynamic interplay between metabolic processes and gene regulation via the remodeling of chromatin. Most chromatin-modifying enzymes use cofactors, which are products of metabolic processes. This article explores the biosynthetic pathways of the cofactors nicotinamide adenine dinucleotide (NAD), acetyl coenzyme A (acetyl-CoA), S-adenosyl methionine (SAM), α-ketoglutarate, and flavin adenine dinucleotide (FAD), and their role in metabolically regulating chromatin processes. A more detailed look at the interaction between chromatin and the metabolic processes of circadian rhythms and aging is described as a paradigm for this emerging interdisciplinary field.

Publication types

  • Review

MeSH terms

  • Chromatin / metabolism*
  • NAD / metabolism
  • Signal Transduction*


  • Chromatin
  • NAD