Discovery of Chemical Inhibitors of Human Bromodomains

Chem Rev. 2015 Nov 11;115(21):11625-68. doi: 10.1021/acs.chemrev.5b00205. Epub 2015 Oct 23.

Authors

Guangtao Zhang¹, Steven G Smith¹, Ming-Ming Zhou¹

Affiliation

¹ Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai , 1425 Madison Avenue, New York, New York 10029, United States.

PMID: 26492937
DOI: 10.1021/acs.chemrev.5b00205

No abstract available

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Acetyltransferases / antagonists & inhibitors*
Acetyltransferases / metabolism
Azepines / chemistry
Azepines / metabolism
Azo Compounds / chemistry
Azo Compounds / metabolism
Carbazoles / chemistry
Carbazoles / metabolism
Diamines / chemistry
Diamines / metabolism
Drug Evaluation, Preclinical
Humans
Protein Binding
Protein Structure, Tertiary
Quinolines / chemistry
Quinolines / metabolism
Small Molecule Libraries / chemistry
Small Molecule Libraries / metabolism*
Transcription Factors / antagonists & inhibitors*
Transcription Factors / metabolism

Substances

Azepines
Azo Compounds
Carbazoles
Diamines
Quinolines
Small Molecule Libraries
Transcription Factors
Acetyltransferases