Ameliorative potential of gingerol: Promising modulation of inflammatory factors and lipid marker enzymes expressions in HFD induced obesity in rats

Mol Cell Endocrinol. 2016 Jan 5;419:139-47. doi: 10.1016/j.mce.2015.10.007. Epub 2015 Oct 19.

Abstract

Obesity, generally linked to hyperlipidemia, has been occurring of late with distressing alarm and has now become a global phenomenon casting a huge economic burden on the health care system of countries around the world. The present study investigated the effects of gingerol over 30 days on the changes in HFD-induced obese rats in marker enzymes of lipid metabolism such as fatty-acid synthase (FAS), Acetyl CoA Carboxylase (ACC), Carnitine Palmitoyl Transferase-1(CPT-1), HMG co-A Reductase (HMGR), Lecithin Choline Acyl Transferase (LCAT) and Lipoprotein Lipase (LPL) and inflammatory markers (TNF-α and IL-6). The rats were treated orally with gingerol (75 mg kg(-1)) once daily for 30 days with a lorcaserin-treated group (10 mg kg(-1)) included for comparison. Changes in body weight, glucose, insulin resistance and expressions of lipid marker enzymes and inflammatory markers in tissues were observed in experimental rats. The administration of gingerol resulted in a significant reduction in body weight gain, glucose and insulin levels, and insulin resistance, which altered the activity, expressions of lipid marker enzymes and inflammatory markers. It showed that gingerol had significantly altered these parameters when compared with HFD control rats. This study confirms that gingerol prevents HFD-induced hyperlipidemia by modulating the expression of enzymes important to cholesterol metabolism.

Keywords: Antiobesity effect; Ginger; Gingerol; High-fat diet; Insulin.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Benzazepines / administration & dosage
  • Benzazepines / pharmacology
  • Biomarkers / metabolism*
  • Body Weight / drug effects
  • Catechols / administration & dosage*
  • Catechols / pharmacology
  • Diet, High-Fat / adverse effects*
  • Fatty Alcohols / administration & dosage*
  • Fatty Alcohols / pharmacology
  • Gene Expression Regulation, Enzymologic / drug effects
  • Insulin Resistance
  • Interleukin-6 / metabolism
  • Lipid Metabolism / drug effects*
  • Male
  • Obesity / chemically induced
  • Obesity / drug therapy*
  • Obesity / metabolism
  • Rats
  • Rats, Wistar
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Benzazepines
  • Biomarkers
  • Catechols
  • Fatty Alcohols
  • Interleukin-6
  • Tumor Necrosis Factor-alpha
  • lorcaserin
  • gingerol