Centrosomes and Cancer: Revisiting a Long-Standing Relationship

Nat Rev Cancer. 2015 Nov;15(11):639-52. doi: 10.1038/nrc3995.

Abstract

Over a century ago, centrosome aberrations were postulated to cause cancer by promoting genome instability. The mechanisms governing centrosome assembly and function are increasingly well understood, allowing for a timely reappraisal of this postulate. This Review discusses recent advances that shed new light on the relationship between centrosomes and cancer, and raise the possibility that centrosome aberrations contribute to this disease in different ways than initially envisaged.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Centrosome / physiology*
  • Chromosome Aberrations*
  • Humans
  • Mitosis / genetics*
  • Neoplasms / genetics*