Non-coding functions of alternative pre-mRNA splicing in development

doi:10.1016/j.semcdb.2015.10.018

Review

. 2015 Dec:47-48:32-9.

doi: 10.1016/j.semcdb.2015.10.018. Epub 2015 Oct 19.

Non-coding functions of alternative pre-mRNA splicing in development

Stefan Mockenhaupt¹, Eugene V Makeyev²

Affiliations

¹ School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.
² School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore; MRC Centre for Developmental Neurobiology, King's College London, London SE1 1UL, UK. Electronic address: eugene.makeyev@kcl.ac.uk.

PMID: 26493705
PMCID: PMC4683092
DOI: 10.1016/j.semcdb.2015.10.018

Review

Non-coding functions of alternative pre-mRNA splicing in development

Stefan Mockenhaupt et al. Semin Cell Dev Biol. 2015 Dec.

. 2015 Dec:47-48:32-9.

doi: 10.1016/j.semcdb.2015.10.018. Epub 2015 Oct 19.

Authors

Stefan Mockenhaupt¹, Eugene V Makeyev²

Affiliations

¹ School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.
² School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore; MRC Centre for Developmental Neurobiology, King's College London, London SE1 1UL, UK. Electronic address: eugene.makeyev@kcl.ac.uk.

PMID: 26493705
PMCID: PMC4683092
DOI: 10.1016/j.semcdb.2015.10.018

Abstract

A majority of messenger RNA precursors (pre-mRNAs) in the higher eukaryotes undergo alternative splicing to generate more than one mature product. By targeting the open reading frame region this process increases diversity of protein isoforms beyond the nominal coding capacity of the genome. However, alternative splicing also frequently controls output levels and spatiotemporal features of cellular and organismal gene expression programs. Here we discuss how these non-coding functions of alternative splicing contribute to development through regulation of mRNA stability, translational efficiency and cellular localization.

Keywords: Alternative pre-mRNA splicing; Development; Translational regulation; mRNA localization; mRNA stability.

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Figures

**Fig. 1**
Role of AS in mRNA stability, translational activity and subcellular localization. Top, examples of relevant AS topologies; mid, mature mRNA containing 5′ and 3′UTRs flanking the protein-coding ORF; bottom, downstream regulation outcomes of AS events in the corresponding regions.

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References

1. Sharp P.A. Split genes and RNA splicing. Cell. 1994;77(6):805–815. - PubMed
1. Han J. Pre-mRNA splicing: where and when in the nucleus. Trends Cell Biol. 2011;21(6):336–343. - PMC - PubMed
1. Kornblihtt A.R. Alternative splicing: a pivotal step between eukaryotic transcription and translation. Nat. Rev. Mol. Cell Biol. 2013;14(3):153–165. - PubMed
1. Matera A.G., Wang Z. A day in the life of the spliceosome. Nat. Rev. Mol. Cell Biol. 2014;15(2):108–121. - PMC - PubMed
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[1] Sharp P.A. Split genes and RNA splicing. Cell. 1994;77(6):805–815. - PubMed

[2] Sharp P.A. Split genes and RNA splicing. Cell. 1994;77(6):805–815. - PubMed

[3] Han J. Pre-mRNA splicing: where and when in the nucleus. Trends Cell Biol. 2011;21(6):336–343. - PMC - PubMed

[4] Han J. Pre-mRNA splicing: where and when in the nucleus. Trends Cell Biol. 2011;21(6):336–343. - PMC - PubMed

[5] Kornblihtt A.R. Alternative splicing: a pivotal step between eukaryotic transcription and translation. Nat. Rev. Mol. Cell Biol. 2013;14(3):153–165. - PubMed

[6] Kornblihtt A.R. Alternative splicing: a pivotal step between eukaryotic transcription and translation. Nat. Rev. Mol. Cell Biol. 2013;14(3):153–165. - PubMed

[7] Matera A.G., Wang Z. A day in the life of the spliceosome. Nat. Rev. Mol. Cell Biol. 2014;15(2):108–121. - PMC - PubMed

[8] Matera A.G., Wang Z. A day in the life of the spliceosome. Nat. Rev. Mol. Cell Biol. 2014;15(2):108–121. - PMC - PubMed

[9] Chen W., Moore M.J. The spliceosome: disorder and dynamics defined. Curr. Opin. Struct. Biol. 2014;24:141–149. - PMC - PubMed

[10] Chen W., Moore M.J. The spliceosome: disorder and dynamics defined. Curr. Opin. Struct. Biol. 2014;24:141–149. - PMC - PubMed

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Non-coding functions of alternative pre-mRNA splicing in development

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Non-coding functions of alternative pre-mRNA splicing in development

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