Monosodium glutamate-induced oxidative kidney damage and possible mechanisms: a mini-review

J Biomed Sci. 2015 Oct 22:22:93. doi: 10.1186/s12929-015-0192-5.

Abstract

Animal studies suggest that chronic monosodium glutamate (MSG) intake induces kidney damage by oxidative stress. However, the underlying mechanisms are still unclear, despite the growing evidence and consensus that α-ketoglutarate dehydrogenase, glutamate receptors and cystine-glutamate antiporter play an important role in up-regulation of oxidative stress in MSG-induced renal toxicity. This review summaries evidence from studies into MSG-induced renal oxidative damage, possible mechanisms and their importance from a toxicological viewpoint.

Publication types

  • Review

MeSH terms

  • Humans
  • Kidney Diseases / chemically induced*
  • Kidney Diseases / metabolism*
  • Oxidative Stress / drug effects*
  • Sodium Glutamate / adverse effects*

Substances

  • Sodium Glutamate