Next-generation sequencing and empowering personalised cancer medicine

Drug Discov Today. 2015 Dec;20(12):1470-5. doi: 10.1016/j.drudis.2015.10.008. Epub 2015 Oct 19.


The announcement earlier this year of the US$1000 genome by Illumina has excited a debate as to when and how genomes will at last transition from the research laboratory to the clinic. Although it is still unclear what the benefit will be to patients, there is sufficient evidence supporting the importance of the genome in driving cancer development, treatment response and drug resistance. Therefore it is reasonable to assume that large-scale stratification of patients using next-generation sequencing technologies will improve patient outcome in at least some common cancer types.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Genome, Human / genetics
  • Genomics / methods
  • High-Throughput Nucleotide Sequencing / methods
  • Humans
  • Neoplasms / drug therapy*
  • Neoplasms / genetics*
  • Precision Medicine / methods