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. 2015 Nov 20;350(6263):957-61.
doi: 10.1126/science.aad1023. Epub 2015 Oct 22.

Cells of a Common Developmental Origin Regulate REM/non-REM Sleep and Wakefulness in Mice

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Cells of a Common Developmental Origin Regulate REM/non-REM Sleep and Wakefulness in Mice

Yu Hayashi et al. Science. .
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Abstract

Mammalian sleep comprises rapid eye movement (REM) sleep and non-REM (NREM) sleep. To functionally isolate from the complex mixture of neurons populating the brainstem pons those involved in switching between REM and NREM sleep, we chemogenetically manipulated neurons of a specific embryonic cell lineage in mice. We identified excitatory glutamatergic neurons that inhibit REM sleep and promote NREM sleep. These neurons shared a common developmental origin with neurons promoting wakefulness; both derived from a pool of proneural hindbrain cells expressing Atoh1 at embryonic day 10.5. We also identified inhibitory γ-aminobutyric acid-releasing neurons that act downstream to inhibit REM sleep. Artificial reduction or prolongation of REM sleep in turn affected slow-wave activity during subsequent NREM sleep, implicating REM sleep in the regulation of NREM sleep.

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