Intratumoral and parametrial infusion of metronidazole in the radiotherapy of uterine cervix cancer: preliminary report

Int J Radiat Oncol Biol Phys. 1989 Apr;16(4):1061-3. doi: 10.1016/0360-3016(89)90916-4.


In a recently started clinical trial, the short-term effects of radiotherapy of cervix cancer Stage IIb and III in combination with topical infusion of metronidazole solution were evaluated by determining the local clearance rate and cytologic damage in randomized and non-randomized cases. In regard to the short term effects the combined treatment was found to be superior to treatment without metronidazole.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Clinical Trials as Topic
  • Combined Modality Therapy
  • Female
  • Humans
  • Metronidazole / administration & dosage
  • Metronidazole / therapeutic use*
  • Random Allocation
  • Uterine Cervical Neoplasms / radiotherapy*


  • Metronidazole